Ten time winners and current Premier League pacesetters Arsenal were paired with Liverpool after their victories over Coventry and Bournemouth respectively.
Manuel Pellegrini's City, winners in 2011 and runners up to Wigan last year, beat Watford in the fourth round on Saturday, while Chelsea booked their passage with a 1 0 victory Puma Ignite Pro Performance
There are four all Premier League ties in total as Everton were drawn against Swansea one of manager Roberto Martinez' former clubs while Sunderland will host Southampton.
Chelsea manager Jose Mourinho said: "No problem. If you want to be the best you have to play against the best, so it's good for us. Good experience, good game, big game.
over Stoke on Sunday, Oscar's Puma Basket Suede
Manchester City will play Chelsea and Arsenal will host Liverpool in the fifth round of the FA Cup.
first half free kick proving decisive.
Manchester City face Chelsea and Arsenal meet Liverpool in draw for the fifth round
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